Advicor Drug Interactions

Drug interactions may occur if Advicor is combined with protease inhibitors, blood pressure medicines, cyclosporine, and antifungals. These medicines can cause your body to metabolize the drugs differently than intended and lead to decreased effectiveness. The risks of developing serious muscle problems may also increase dramatically. If drug interactions with Advicor are a concern, your doctor may either monitor you more closely or make dosing adjustments.

Advicor Interactions: An Overview

 Advicor® (niacin extended-release/lovastatin) can potentially interact with a number of other medicines. Some of the medications that may lead to drug interactions with Advicor include:
 
 
 
  • Certain antifungals, such as:
     
    • Fluconazole (Diflucan®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Posaconazole (Noxafil®)
    • Voriconazole (VFEND®)
 
 
  • Grapefruit juice
  • Nefazodone (Serzone®)
  • Nitrates, such as:
     
    • Isosorbide dinitrate (BiDil®, Dilatrate® SR, Isochron™, Isordil®)
    • Isosorbide mononitrate (Imdur®, Ismo®, Monoket®)
    • Nitroglycerin tablets or capsules (NitroQuick®, Nitrostat®, Nitro-Time®)
    • Nitroglycerin ointment (Nitro-Bid®)
    • Nitroglycerin patches (Minitran®, Nitrodisc®, Nitro-Dur®, Transderm-Nitro®, Transderm-NTG®)
    • Nitroglycerin spray (Nitrolingual®)
 
 
Some of these drug interactions may increase your risk for developing serious muscle problems (see Advicor and Muscle Pain). For people taking Advicor, if you experience unexplained muscle pain, tenderness, or weakness (especially if accompanied by a fever or feeling of illness), it is important to contact your healthcare provider immediately.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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