Your dose of Advicor is based on several factors, such as the condition being treated, your age, and your cholesterol goal. The recommended starting dosage for most people is 500 mg/20 mg once a day. The dose may be altered throughout your treatment process, depending on your reaction to Advicor and whether your cholesterol goals are reached. However, the dose should not exceed 2000 mg/40 mg.
The dosage of Advicor® (niacin extended-release/lovastatin) your healthcare provider recommends will vary, depending on a number of factors, including:
- Your age
- The medical condition you are being treated for
- Other medical conditions you may have
- Other medications you may be currently taking (see Advicor Drug Interactions)
- Your cholesterol goal
- How you respond to the medication.
As is always the case, do not adjust your dose unless specifically instructed to do so by your healthcare provider.
The recommended starting Advicor dose for most people with high cholesterol is 500 mg/20 mg once a day, taken at bedtime with a low-fat snack.
Your healthcare provider may increase your dose if necessary. This must be done slowly to minimize flushing due to the niacin component of the medication. It is recommended to increase the dose no more rapidly than by 500 mg (based on the niacin component) every four weeks. If you stop taking Advicor for seven days or longer, you will need to be restarted on the lowest dosage (Advicor 500 mg/20 mg a day) and slowly increased to your previous dose.
The dosage can also be decreased if Advicor side effects occur. The maximum recommended daily dosage of Advicor is 2000 mg/40 mg. Lower doses may be recommended in some people, including people with severe kidney disease or people who take certain other medications (see Advicor Drug Interactions).
There is no way to take less than 20 mg of the lovastatin component while taking Advicor, since the tablets cannot be split. Therefore, if a lower lovastatin dosage is recommended in your particular situation, this medication is not a good choice for you.
In order to minimize flushing, your healthcare provider may recommend taking aspirin or other similar nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen. This works best if you take the aspirin or NSAID about 30 minutes before your Advicor dose. Be sure to check with your healthcare provider first, since there may be a reason why you should not take aspirin or an NSAID.
It is important to remember that lowering cholesterol begins with lifestyle changes (such as weight loss, low-cholesterol diet, and exercise). Advicor is for use if lifestyle changes do not lower cholesterol to a desirable level. However, even for those who are taking cholesterol medication, lifestyle changes are still important for maintaining a good cholesterol level.